Skip to main content

Table 2 Top 20 protein-protein interactions from occurrence ranking

From: Inferring high-confidence human protein-protein interactions

 

Proteini

  

Proteinj

 

Protein-protein interactioni-j

Symbol

Occurrence

Name

Symbol

Occurrence

Name

Occurrence

O ij

Z-score

Z-rank

Average rank

MDM2

466

Mouse double minute 2 homolog

TP53

1097

Tumor protein p53

130

86.0

3355

2999.8

TP53

1097

Tumor protein p53

UBC

1899

Ubiquitin C

64

18.4

30486

16565.3

HBA2

68

Hemoglobin, alpha 2

HBB

76

Hemoglobin, beta

59

395.5

76

1360.3

CBL

414

Cas-Br-M ecotro- pic sequence

EGFR

626

Epidermal growth factor receptor

46

42.6

11054

6849.3

CBL

414

Cas-Br-M ecotro- pic sequence

GRB2

916

Growth factor receptor bound 2

44

33.2

15615

9129.8

FANCA

217

Fanconi anemia, complementation A

FANCG

143

Fanconi anemia, complementation G

43

117.3

1808

2226.3

EGFR

626

Epidermal growth factor receptor

UBC

1899

Ubiquitin C

41

15.8

34796

18720.3

BRCA2

199

Breast cancer 2, early onset

RAD51

171

DNA repair protein RAD51 homolog 1

40

104.4

2288

2466.3

HIF1A

207

Hypoxia inducible factor 1, alpha

VHL

351

von Hippel-Lindau tumor suppressor

39

69.2

5071

3857.8

HRAS

164

Ha-Ras1 proto-oncoprotein

RAF1

281

Proto-oncogene c-RAF

38

84.8

3444

3044.3

SNAP25

131

Synaptosomal-associated protein, 25kDa

STX1A

183

Syntaxin 1A

37

114.7

1920

2282.3

MAX

145

MYC associated factor X

MYC

382

Proto-oncogene c-Myc

36

73.4

4568

3606.3

BARD1

109

BRCA1 assoc. RING domain 1

BRCA1

448

Breast cancer 1, early onset

35

75.9

4279

3461.8

GRB2

916

Growth factor receptor bound 2

SHC1

317

SHC transforming protein 1

35

30.1

17593

10118.8

CDH1

167

Cadherin 1, type 1

CTNNB1

470

Catenin, beta 1

34

57.8

6876

4760.3

E2F1

168

E2F transcription factor 1

RB1

385

Retinoblastoma 1

34

64.0

5853

4248.8

GRB2

916

Growth factor receptor bound 2

SOS1

125

Son of sevenless homolog 1

32

44.9

10232

6438.3

CCNA2

109

Cyclin A2

CDK2

286

Cyclin-dependent kinase 2

31

84.3

3485

3064.8

EGF

76

Epidermal growth factor

EGFR

626

Epidermal growth factor receptor

31

68.2

5211

3927.8

NFKBIA

231

Nucl. factor of kappa light chain gene enhancer in B-cells

RELA

314

V-rel reticulo-endotheliosis viral oncogene homolog A

30

53.1

7932

5288.3

  1. Top 20-ranked protein-protein interactions (PPIs), as identified by the number of times they were observed in the aggregated data set. The quantities and calculations are annotated as in Table 1, except that the data were sorted in decreasing order of PPI occurrence O ij . The proteins involved in these interactions are easily recognizable, and this partly reflects an underlying study-bias of focusing research efforts on a smaller set of high-interest proteins.