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Table 4 Domain-domain interaction enrichment

From: Inferring high-confidence human protein-protein interactions

Reference set

IDBOS

Hypergeometric

Occurrence

Random rank

 

Fraction

Gain

Fraction

Gain

Fraction

Gain

Fraction

DDI

0.225

48%

0.215

42%

0.174

15%

0.152

  1. The fraction of true domain-domain interactions (DDIs) retrieved with interaction detection based on shuffling (IDBOS), hypergeometric test ranking, occurrence ranking, and randomly ranked data. We calculated the reported fraction and gain associated with the different ranking schemes as outlined in Equations 3 and 4. We tested whether the numerical differences in the fraction values for each pairwise comparison were due to chance using the t-test, and rejected this hypothesis with a p-value of <10-24.