Skip to main content

Table 6 OverlapPlus matching

From: Matching of array CGH and gene expression microarray features for the purpose of integrative genomic analyses

Step 1

Apply the overlap matching procedure.

Step 2

For all unmatched genes, the closest DNA copy number feature down- and upstream are

determined.

Step 3

Per gene, assess whether any of the samples in the dataset exhibits a breakpoint (i.e., a change in the segmented DNA copy number) in between the genes closest down- and upstream feature. If no breakpoint is present (the top panel of Figure 6), assign the DNA copy number data of the closest feature to the gene. If, any of the samples reveals a breakpoint (the bottom panel of Figure 6), the gene is left unmatched. For it could not be decided whether the closest down- or upstream feature contains the correct DNA copy number data.