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Figure 3 | BMC Bioinformatics

Figure 3

From: Deterministic global optimization algorithm based on outer approximation for the parameter estimation of nonlinear dynamic biological systems

Figure 3

Optimization algorithm based on outer approximation. Our approach decomposes the problem into two subproblems: a master MILP, constructed by relaxing the original model using piecewise McCormick envelopes and hyper-planes, that provides a lower bound, and a slave NLP that yields an upper bound. The algorithm iterates between these two levels until a termination criterion is satisfied.

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