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Figure 4 | BMC Bioinformatics

Figure 4

From: Deterministic global optimization algorithm based on outer approximation for the parameter estimation of nonlinear dynamic biological systems

Figure 4

McCormick convex relaxation over the entire feasible region (subfigure (a)) compared to a piecewise McCormick relaxation over a smaller active region (subfigure (b)) where the tightness of the relaxation is improved. We built the master problem by replacing the bilinear terms by piecewise McCormick envelopes. The relaxation can be further improved by adding binary variables.

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