Figure 7From: Deterministic global optimization algorithm based on outer approximation for the parameter estimation of nonlinear dynamic biological systemsProposed mechanism describing the irreversible inhibition of HIV proteinase. The enzyme HIV proteinase (E), which is only active in a dimer form, was added to a solution of an irreversible inhibitor (I) and a fluorogenic substrate (S). The product (P) is a competitive inhibitor for the substrate.Back to article page