Figure 1

Inversion Signatures. The figure shows two regions with inversion signatures. The region a₁–a₂ in the draft genome matches regions b₁ and b₃ in the reference genome. b₁ and b₃ are not consecutive in the reference genome and hence this defines a breakpoint; moreover, because the match between a₁ and b₁ has a diffferent orientation as compared to the match between a₂ and b₃ this breakpoint is an inversion signature. The same happens with region a₃–a₄ of the draft genome and regions b₂ and b₄ of the reference genome. Both ISs are related because they are the result of the same inversion event. Therefore these two ISs constitute an IS pair.