Figure 4
Combined XOR phenotype is formed by HGT between cells evolved in single A and B environments. (A) Microarray-like expression levels with one epoch (4500 time steps) for three cells from left to right: donor cell for the HGT transfer evolved in the B environment (highlighted triplets T0, T4-T6 form a minimal network), recipient cell evolved in the A environment (triplets T0-T3 is the minimal network), and a final combined cell with a minimal network T0-T6. Shaded expression levels are for triplets outside the minimal functional network. Environmental signals and the nutrient abundance as a function of time are shown at the top in green and grey, respectively. The Pearson correlation between expression levels of the modified protein from the metabolic pathway RP0 (bottom row in metabolic pathway T0) and nutrient abundance is the fitness of the cell w. (B) Corresponding gene regulatory and biochemical networks (only minimal networks are shown). Network for cell of type A (recipient cell) is shown on the solid yellow background. Triplets transferred in HGT fragment from the cell of type B are enclosed in the dashed segment on the right. Each triplet (T1-T6, and the metabolic triplet T0 on the left) consists of three nodes from bottom to top: mRNA, protein, and modified protein. Red and blue arrows show activation and inhibition (strength of regulation is not shown). Regulation by two external signals S1 and S2 is shown with green arrows.