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Table 3 Proprieties of distribution of fitness effect

From: Horizontal gene transfer dynamics and distribution of fitness effects during microbial in silico evolution

 

Mean fitness change, %

Fitness variance

Skewness

Kurtosis

Percent of lethal events

Mutations

     

Un-evolved populations

-6.6%

0.109

-0.014

3.10

33.0%

Evolved populations

-4.5%

0.032

-1.028

6.39

3.2%

Horizontal gene transfer

     

Un-evolved populations

-5.1%

0.063

-0.129

4.49

14.4%

Evolved populations

-6.6%

0.048

-0.064

4.70

4.6%

Experimental values (mutations)

     

VSV RNA virusa

-6.4%

   

26.4%

Bacteriophage f1b,d

-10.7%

0.037

-1.909

3.16

21.0%

Qβ bacteriophagec,d

-10.3%

0.018

-1.167

0.24

28.6%

E. coli (insertions)e

-3.2% to -1.2%

< 0.01

  

< 5%

  1. DFE for mutation and HGT events in evolved and un-evolved populations. Calculated DFE and an overview of the experimental data for mutation events for comparison.
  2. a Single nucleotide substitutions in vesicular stomatitis virus [35].
  3. b Single nucleotide substitutions in Bacteriophage f1 [34].
  4. c Mutation accumulation experiment for Qβ bacteriophage [33].
  5. d Summary of results for mutation effects in RNA and single stranded DNA viruses [36].
  6. e Mini-Tn10 transposon insertions in E. coli [31].