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Table 3 Proprieties of distribution of fitness effect

From: Horizontal gene transfer dynamics and distribution of fitness effects during microbial in silico evolution

  Mean fitness change, % Fitness variance Skewness Kurtosis Percent of lethal events
Mutations      
Un-evolved populations -6.6% 0.109 -0.014 3.10 33.0%
Evolved populations -4.5% 0.032 -1.028 6.39 3.2%
Horizontal gene transfer      
Un-evolved populations -5.1% 0.063 -0.129 4.49 14.4%
Evolved populations -6.6% 0.048 -0.064 4.70 4.6%
Experimental values (mutations)      
VSV RNA virusa -6.4%     26.4%
Bacteriophage f1b,d -10.7% 0.037 -1.909 3.16 21.0%
Qβ bacteriophagec,d -10.3% 0.018 -1.167 0.24 28.6%
E. coli (insertions)e -3.2% to -1.2% < 0.01    < 5%
  1. DFE for mutation and HGT events in evolved and un-evolved populations. Calculated DFE and an overview of the experimental data for mutation events for comparison.
  2. a Single nucleotide substitutions in vesicular stomatitis virus [35].
  3. b Single nucleotide substitutions in Bacteriophage f1 [34].
  4. c Mutation accumulation experiment for Qβ bacteriophage [33].
  5. d Summary of results for mutation effects in RNA and single stranded DNA viruses [36].
  6. e Mini-Tn10 transposon insertions in E. coli [31].