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Table 2 Protein co-localization for 28 experiment sources in the BioGRID database.

From: Predicting multiplex subcellular localization of proteins using protein-protein interaction network: a comparative study

Experiment system

Throughput technique

number of interactions

number of common l localizations

   

≥ 1 (reliability)

≥ 2

Affinity Capture-Luminescence

low throughput

29

0.3448

0

Affnity Capture-MS

high throughput

44399

0.5343

0.0798

 

low throughput

5627

0.5873

0.0945

Affnity Capture-RNA

high throughput

3657

0.2625

0.0014

 

low throughput

86

0.3140

0.0581

Affinity Capture-Western

high throughput

213

0.6526

0.0798

 

low throughput

11257

0.5477

0.0759

Biochemical Activity

high throughput

4211

0.3363

0.0686

 

low throughout

3427

0.4471

0.1100

Co-crystal Structure

low throughput

364

0.6593

0.1703

Co-fractionation

high throughput

102

0.0098

0

 

low throughput

585

0.4821

0.0598

Co-localization

low throughput

448

0.5357

0.0588

Co-purification

high throughput

11

0.8182

0.5455

 

low throughput

1667

0.6155

0.0834

FRET

high throughput

13

0.1538

0

 

low throughput

121

0.6364

0.0579

Far Western

low throughput

74

0.5811

0.0541

 

high throughput

4738

0.4185

0.0319

PCA

low throughput

409

0.5232

0.0098

 

high throughput

9

0.3140

0

Protein-RNA

low throughput

168

0.1116

0.0129

 

high throughput

328

0.3333

0

Protein-peptide

low throughput

233

0.4940

0.0833

 

high throughput

27

0.5556

0.0370

Reconstructed Complex

low throughput

3347

0.5088

0.0986

 

high throughput

6624

0.3578

0.0773

Two-hybrid

low throughput

4622

0.4799

0.1019