Figure 6

A phylogenetic tree of the two predicted lineage-unique ABC transporter families and antibiotic related ABC transporters from Streptomyces. The ABC transporters are divided into three classes. Type I: DrrA, S. peucetius; MtrA, S. argillaceus; KasK, S. kasugaensis; TnrB2, S. longisporoflavus; Type II: LmrC, S. lincolnensis; VarM, S. virginiae; OleB, S. antibioticus; SrmB, S. ambofaciens; CarA, S. thermotolerans; TlrC, S. fradiae; Type III: NovA, S. sphaeroides; NysG, NysH, S. noursei; StrW, StrV, S. glaucescens. The lineage-unique families are highlighted in green. The ABC transporters with proved antibiotic resistance function are highlighted in blue, and those not yet tested are highlighted in grey. Tree was inferred by the neighbor-joining method based on the amino acid sequences with Poisson corrected distance. The option of complete deletion of gaps was used for tree construction. 1,000 bootstrap replicates were used to infer the reliability of branching points. Bootstrap values of > 50% are presented. The scale bar indicates the number of amino acid substitutions per site. The Maximum Likelihood and Maximum Parsimony methods give virtually the same topology (data not shown).