Modelling osteomyelitis

BMC Bioinformatics

Table 2 Model parameters.

Parameter	Description	Value
(α₁, α₂)	O_c and O_b growth rates	(3, 4) day^-1
(β₁, β₁)	O_c and O_b death rates	(0.2, 0.02) day^-1
(g₁₁, g₁₂, g₂₂, g₂₁)	Effectiveness of autocrine/paracrine regulation	(1.1, 1, 0, -0.5)
(k₁, k₂)	Resorption and formation rates	(0.0748, 0.0006395) day^-1
g_ageing	Ageing factor	2
g_por	RANKL factor	0.1
γ_B	S. aureus growth rate	0.005 day^-1
s	S. aureus carrying capacity	100
V	Effectiveness of antibiotic treatment	(0.005, 0.007) day^-1
t _treat	Dosage time	(200, 400, 600) days
(f₁₁, f₁₂, f₂₂, f₂₁)	Effect of infection on regulation factors	(0.005, 0, 0.2, 0.005) day^-1
$(\bar{O_{c}}, \bar{O_{b}})$	Steady levels of O_c and O_b	Control: (1.16, 231.72)
		Osteoporosis: (1.78, 177.91)
		Osteomyelitis: (5, 316)
(O_{c 0}, O_{b 0}, B₀)	Initial states	Control: (11.16, 231.72, 1)
		Osteoporosis: (11.78, 177.91, 1)
		Osteomyelitis: (15, 316, 1)

Values have been adapted from literature (mainly [10, 16]). Some parameters are specific to a particular scenario: g_ageing and g_por are relative to the osteoporosis model, while parameters γ_B, s, V, t_treat and (f₁₁, f₁₂, f₂₂, f₂₁) are specific to the osteomyelitis model.

ISSN: 1471-2105