Figure 4

Web Interface Structure. a) Query by genes or proteins. For example, UniGene IDs, Entrez gene IDs, gene names, UniProt IDs, UniProt Accessions or IPI IDs are all supported. To enter multiple values, delimit them by comma, semi-colon, line or space. b,c,d,e) search result. In the enrichment analysis table, it shows Pathway ID (Disease ID, Drug ID, Organ ID), Pathway Name (Disease Name, Drug Name, Organ Name), Molecule, significance (AE, RE, N, MJI, p-value), and inter-association. For each enriched component, users can further browse the inter-association between its molecule and pathway, disease, drug and organ by clicking on the link in the column of molecule, and its inter-association between pathway, disease, drug and organ by clicking on the inter-association icon in the last column. f) molecule inter-association. It shows molecule, Gene Symbol, Pathway ID (Disease ID, Drug ID, Organ ID), and Pathway Name (Disease Name, Drug Name, Organ Name). g,h,i,j) inter-association between pathway, disease, drug and organ. It shows associations between Pathway-Pathway, Pathway-Disease, Pathway-Drug, Pathway-Organ, Disease-Pathway, Disease-Disease, Disease-Drug, Disease-Organ, Drug-Pathway, Drug-Disease, Drug-Drug, Drug-Organ, Organ-Pathway, Organ-Disease, Organ-Drug, Organ-Organ, and their significance (AE, RE, MJI, p-value).