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Figure 3 | BMC Bioinformatics

Figure 3

From: Knowledge-based analysis of proteomics data

Figure 3

Interactome analysis of proteomics datasets and gene lists. A. The general schema of interactions inside the set, between the sets and between the set and "global interactome". B. The "over" and "under"-connectivity phenomenon. The hub (P21 protein from MetaCore database, marked pink) is expected to be linked with five other proteins in the hypothetical dataset of 320 genes (purple circles), but in reality is can be linked with nine genes (purple and green circles), or 3 genes (purple circles). In these cases, it will be considered as "over" connected or "under" connected.

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