Table 3 The highest scored topologically significant proteins from gene expression and proteomics data for androgen-stimulated LNCaP prostate cancer cells
Symbol | Entrez Gene ID | Description | p value |
|---|---|---|---|
AAG11 | 2274 | aging -associated gene 11 | 2.24E-19 |
CLS | 6197 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 1.51E-18 |
CTNNB | 1499 | catenin (cadherin -associated protein), beta 1, 88kDa | 5.45E-17 |
CCND2 | 894 | cyclin D2 | 3.74E-16 |
FLJ21396 | 23132 | RAD54 -like 2 | 5.26E-16 |
AIS | 367 | androgen receptor | 1.36E-15 |
DAB2 | 1601 | mitogen -responsive phosphoprotein | 1.55E-15 |
ABP -280 | 2316 | filamin A, alpha | 3.89E-15 |
ACH | 2261 | fibroblast growth factor receptor 3 | 1.2E-14 |
RAD9 | 5883 | RAD9 homolog | 1.31E-14 |
Symbol | Entrez Gene ID | Description | p value |
MYC | 4609 | myc proto-oncogene protein | 2.15E-08 |
HIRS-1 | 3667 | insulin receptor substrate 1 | 1.85E-07 |
BCL2 | 596 | B-cell CLL/lymphoma 2 | 4.21E-07 |
INSRR | 3645 | IR-related receptor | 4.34E-07 |
MGC26306 | 9414 | tight junction protein 2 (zona occludens 2) | 4.38E-07 |
GCCR | 2908 | glucocorticoid receptor | 5.98E-07 |
IRF-1 | 3659 | interferon regulatory factor-1 | 1.01E-06 |
SREBF1 | 6720 | sterol regulatory element binding transcription factor 1 | 1.06E-06 |
FLJ12859 | 23528 | ZNP-99 transcription factor | 1.1E-06 |
ETV3 | 2117 | ets variant gene 3, ETS family transcriptional repressor | 1.12E-06 |