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Figure 10 | BMC Bioinformatics

Figure 10

From: Functional relevance of dynamic properties of Dimeric NADP-dependent Isocitrate Dehydrogenases

Figure 10

Principal Component analysis. Porcupine plots [59] for (a) EcIDH and (b)PmIDH. Only Cα atoms are shown for First PCA mode. The loop present at top and bottom of structure is the ARS region. Subfamily I show localized loop motion in a rotatory fashion around the central domain. Subfamily II shows tandem motion - as one site closes, the other opens. The loops are mobile, and may play a role to guide substrate and cofactor to the active site. The summary plots are provided [see Additional file 4].

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