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Table 1 IDH representative structures.

From: Functional relevance of dynamic properties of Dimeric NADP-dependent Isocitrate Dehydrogenases

Type

Organism

Short Name

Uniprot

PDB id

Resolution

(Ã…)

Length

I

Escherischia coli

EcIDH

IDH_ECOLI

3ICD

2.5

416 × 2

I

Bacillus subtilis

BsIDH

IDH_BACSU

1HQS

1.55

423 × 2

I

Aeropyrum pernix

ApIDH

Q9YE81_AERPE

1TYO

2.15

435 × 2

I

Burcholderi apseudomallei

BpIDH

Q63WJ4_BURPS

3DMS

1.65

427 × 2

II

Mycobacterium tuberculosis

MtIDH1

IDH_MYCTU

Model

NA

407 × 2

II

Homo sapiens (cytoplasmic)

HcIDH

IDHC_HUMAN

1T0L

2.41

414 × 2

II

Saccharomyces cerevisiae (mito.)

YmIDH

IDHP_YEAST

2QFW

2.6

427 × 2

II

Sus scrofa (mitochondrial)

PmIDH

IDHP_PIG

1LWD

1.85

413 × 2

II

Thermotoga maritima

TmIDH

Q9X0N2_THEMA

1ZOR

2.24

399 × 2

IV

Thermus thermophilus

TtIDH

IDH_THET8

2D1C

1.8

495 × 2

  1. At most four representatives of each type (I, II and IV) of NADP-dependent IDH were chosen for simulation, in addition to the model of MtIDH1. Ligands and metal ions were removed, as they are different in each case. Uniprot sequences may be longer than PDB lengths given here, due to unresolved terminal residues. These residues were not modelled. Monomeric IDHs (M) were simulated but results are not discussed here. The data of the monomeric type is provided here for completeness and comparison purposes.