Figure 4

GAR transformylase detailed plans. Shown are the locations of selected mutations (vertical lines) and resulting runs of length ≥ 9 (boxes; staggered at some locations to avoid overlap), optimized under different objectives. For f₂, runs are colored by length, with 6:green, 7:black, 8:magenta, ≥ 9:blue. For 0 mutations, all methods yielded the same run pattern, so only the f₂ version is shown.