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Table 2 Statistical significance test of the performance between two methods

From: Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee

SP

MSAProbs

Kalign

PROMALS

MAFFT

ProbCons

PRALINE™

PSI-Coffee

MSAProbs

NA

0.014

0.547

0.483

0.675

0.779

0.726

Kalign

0.014

NA

0.195

0.039

0.008

0.195

0.078

PROMALS

0.547

0.195

NA

0.575

0.742

0.742

0.528

MAFFT

0.483

0.039

0.575

NA

0.889

0.844

0.779

ProbCons

0.675

0.008

0.742

0.889

NA

0.461

0.262

PRALINE™

0.779

0.195

0.742

0.844

0.461

NA

0.641

PSI-Coffee

0.726

0.078

0.528

0.779

0.262

0.641

NA

TC

MSAProbs

Kalign

PROMALS

MAFFT

ProbCons

PRALINE™

PSI-Coffee

MSAProbs

NA

0.035

0.150

0.529

1.000

0.779

0.204

Kalign

0.035

NA

0.742

0.078

0.055

0.272

0.014

PROMALS

0.150

0.742

NA

0.529

0.362

0.624

0.233

MAFFT

0.529

0.078

0.529

NA

0.362

0.945

0.262

ProbCons

1.000

0.055

0.362

0.362

NA

1.000

0.353

PRALINE™

0.779

0.272

0.624

0.945

1.000

NA

0.195

PSI-Coffee

0.204

0.014

0.233

0.262

0.353

0.195

NA

  1. Wilcoxon Signed-Rank Test (R: wilcoxon.test, paired = TRUE)
  2. NULL hypothesis: x and y have identical performance
  3. 0.05 significance level: p-value smaller than 0.05 marked in bold, reject null hypothesis