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Figure 2 | BMC Bioinformatics

Figure 2

From: The impact of quantile and rank normalization procedures on the testing power of gene differential expression analysis

Figure 2

Medians of the t -statistic absolute values. Medians of the absolute values of the t-statistics for data with and without quantile normalization. Gene expression are simulated by using normal random numbers with standard deviation 0.35 and gene-gene correlation 0.9. Total number of genes is m = 1000. Total numbers of truly differentially expressed genes are m 1 + =60 for up-regulated genes and m1- = 40 for down-regulated genes. The sample size is n = 10 and the true effect size is e+ = -e- = e = {0,0.2,0.4, …,3.6}. Estimates are based on 200 repetitions.

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