Figure 5

Dependence on the initial number of cancer cells. The relative number of cancer cells after one year of treatment compared to the tumour size at the beginning of the simulation is depicted. The mean number of cancer cells at the end of simulation is shown. Data were obtained from 1,000 simulations. The number of cancer cells at the beginning of the simulation is given in the legend. MHC-genotype is HLA-A*01 | HLA-B*08 | HLA-DRB3 | HLA-DPA1/DPB1. For all experiments, simulation space was 5 μl of blood and injections of peptides emulgated in adjuvant started at time point zero being repeated five times at an interval of 28 days. The antigen A0PHL1_HUMAN (RAS-like family 11 member B variant A) was chosen from over-expression data in prostate tumours. Two MHC I-binding peptides and two MHC II-binding peptides were injected.