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Table 2 Rank of entries from the ChEA gene-set library using the three scoring methods implemented in Enrichr given input of lists of up or down regulated genes indentified from studies that profiled gene expression after knockdown or knockout of the same transcription factors

From: Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

TF Up/Down PMID Rank p-value Rank z-score Rank combined
Nanog Up 16518401 1,4,5,16, 2,4,15,18,22, 1,5,12,16,18,
    28,33,62,144 28,33,116 28,37,117
Nanog Down 16518401 5,11,14,16, 1,3,4,20,41, 1,6,12,15,18,
    39,58,78,92 54,61,64 56,70,73
Pou5f1 Up 16518401 3,11,12,18, 1,4,12,23, 1,8,14,15,
    27,71,81 33,35,36 21,50,54
Pou5f1 Down 16518401 32,64,78,156, 1,65,92,121, 23,52,90,127,
    176,181,204 160,165,188 171,176,192
Nanog Up 16767105 3,7,12,18,38, 1,3,11,17,21, 3,5,9,12,25,
    46,56,113 23,26,69 29,36,80
Nanog Down 16767105 18,28,79,89, 4,17,21,33,44, 23,25,35,48,
    92,102,160,164 83,139,157 60,86,142,186
Pou5f1 Up 16767105 1,9,18,23,31, 2,5,10,20, 1,2,16,20,
    82,120,183 30,34,79 23,55,88
Pou5f1 Down 16767105 25,44,124,166, 47,49,60,131, 43,44,74,134,
    167,180,216 139,169,200 147,153,177
Sox2 Up 16767105 2,10,35,59,61, 11,15,26,36, 3,9,26,44,
    70,121 68,71,103 58,80,123
Sox2 Down 16767105 5,44,50,130, 10,72,85,106, 1,61,82,108,
    139,149,176 110,140,151 116,166,177
Sox2 Up 17515932 2,14,15,41,50, 6,27,30,35, 2,7,24,39,44,
    61,82 44,49,55 45,57
Sox2 Down 17515932 8,19,68,93,117, 6,29,73,95, 4,17,84,103,
    164,216 124,146,210 132,151,168
klf4 Up 18264089 1,27,31,183 6,22,31,199 1,23,31,210
klf4 Down 18264089 61,71,163,200 78,85,190,222 78,79,209,219
Zfp281 Up 18757296 3,24 3,6 3,6
Zfp281 Down 18757296 60,159 63,138 64,147
chd1 Up 19587682 126 106 107
chd1 Down 19587682 231 214 125
Tbx3 Up 20139965 110 96 96
Tbx3 Down 20139965 93 70 76