Figure 2

Schematic models for Cancergrid TMA database. (a) Class model to show the relationships between the entities required for tracking and scoring TMA core images within a ‘TMASlide’. The model shows the data used to track the scores for a specific image back to the ‘DonorBlock’, associated with an individual patient. Patient details are not stored in the database. This is a conceptual model from which the XML schema is derived. The database stores XML files corresponding to this schema, which specify the relationship between ‘TMASlide’, associated core images, coordinates of associated ‘Cores’ and a set of manual scores. ScoreAllred represents an Allred score, a type of ScoreManual. Aggregation relationships between ‘DonorBlock’, ‘Core’ and ‘TMARecipientBlock’, show that one or more ‘Cores’ are taken from a ‘DonorBlock’ and a TMARecipientBlock is composed of many ‘Cores’ (these relationships are specified in the Genetix slidemap schema). (b) The database collection hierarchy. XML files (‘TMASlide’) are associated with a particular ‘Scorer’ (a pathologist with a username a password to login to the system). The ‘Scorer’ collection is part of the ‘Marker’ collection (slide stain) and there can be multiple ‘Marker’ collections associated with a particular study.