BMC Bioinformatics

Table 2 Sensitivity and specificity before and after family adjustment in simulation study

From: Copy number variation genotyping using family information

	Sensitivity
	SNR	3	4	5	6	7
MAF=0.1	Unadjusted	0.9095	0.9240	0.9773	0.9942	0.9988
	Family adjusted	0.7106	0.9114	0.9757	0.9937	0.9987
MAF=0.2	Unadjusted	0.9340	0.9777	0.9946	0.9990	0.9991
	Family adjusted	0.8828	0.9698	0.9922	0.9984	0.9997
MAF=0.3	Unadjusted	0.9368	0.9796	0.9925	0.9852	0.9812
	Family adjusted	0.8570	0.9733	0.9950	0.9990	0.9991
	Specificity
	SNR	3	4	5	6	7
MAF=0.1	Unadjusted	0.2867	0.9789	0.9946	0.9990	0.9999
	Family adjusted	0.9411	0.9864	0.9961	0.9993	0.9999
MAF=0.2	Unadjusted	0.8975	0.9591	0.9776	0.8582	0.6295
	Family adjusted	0.9468	0.9740	0.9917	0.9981	0.9997
MAF=0.3	Unadjusted	0.9353	0.9800	0.9919	0.9812	0.9760
	Family adjusted	0.8991	0.9684	0.9927	0.9984	0.9990
	Overall accuracy
	SNR	3	4	5	6	7
MAF=0.1	Unadjusted	0.5253	0.9707	0.9838	0.9878	0.9888
	Family adjusted	0.9274	0.9697	0.9838	0.9878	0.9888
MAF=0.2	Unadjusted	0.9244	0.9704	0.9620	0.8996	0.7848
	Family adjusted	0.9152	0.9708	0.9915	0.9980	0.9997
MAF=0.3	Unadjusted	0.8761	0.9709	0.9895	0.9809	0.9761
	Family adjusted	0.8282	0.9545	0.9896	0.9977	0.9987

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