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Table 1 Comparison of Reactome biological pathways

From: MIMO: an efficient tool for molecular interaction maps overlap

Query

Reactome

 

MIMO

 

SAGA

 

Top-Hit(s)

Score

 

Top-Hit(s)

Score

AUC

 

Top-Hit(s)

Score

AUC

R75829

R11061,R9417,

1.0000

 

R11061

0.8105

0.99

 

R11061,R9417,

117

0.88

 

R16888,R111040,

      

R16888,R111040,

  
 

R9470

      

R9470

  

R634

R9470,R9417,

1.0000

 

R9470,R9417,

0.9778

1.00

 

R9470,R9417,

66

1.00

 

R498,R16888,

  

R498,R16888,

   

R498,R16888,

  
 

R111040,R11061,

  

R111040,R11061

   

R111040,R11061,

  
 

R6900

      

R6900

  

R383

R152

1.0000

 

R152

1.0000

1.00

 

R152

291

1.00

R111064

R9470,R9417,

1.0000

 

R9470,R9417,

0.9778

0.96

 

N/A

-

-

 

R16888,R11061

  

R16888,R11061

      

R1675

R71

0.8254

 

R71

0.8087

1.00

 

R71

504

0.75

R16888

R11061,R9417

0.6875

 

R11061

0.6600

0.96

 

R11061,R9417,

399

0.80

 

R9470

      

R9470

  

R9417

R9470

0.5490

 

R9470

0.5451

0.95

 

R9470,R16888,

480

0.80

        

R11061

  

R1788

R71

0.5333

 

R71

0.5224

0.99

 

R71

409

0.75

R111040

R9470,R9417,

0.5068

 

R9470

0.5160

0.99

 

R9470, R9417,

360

1.00

 

R16888,R11061

      

R16888,R11061

  

R9470

R9417

0.5000

 

R11061

0.5196

0.96

 

R9417,R16888,

534

0.80

        

R11061

  

R13552

R604

0.4384

 

R604

0.4329

1.00

 

R604

431

0.75

R11061

R9470, R9417,

0.3313

 

R9470

0.3495

0.96

 

R9470, R9417,

819

0.80

 

R16888

      

R16888

  

R152

R383

0.3043

 

R383

0.3067

0.98

 

R383

870

1.00

R71

R1675

0.2989

 

R1675

0.2928

0.88

 

R17015

1275

0.85

R498

R11061

0.2985

 

R11061

0.4492

1.00

 

R11061,R6900

315

1.00

        

R634,R16888

315

 
        

R111040,R9417

315

 
        

R9470

315

 

R17015

R71

0.2115

 

R71

0.2008

1.00

 

R71

744

1.00

R111057

R6844

0.1667

 

R6844

0.2333

1.00

 

N/A

-

-

R1538

R152

0.1622

 

R152

0.3102

1.00

 

N/A

-

-

R474

R15518

0.1569

 

R15518

0.2220

0.91

 

R1505

354

0.60

R13433

R22258

0.1562

 

R22258

0.2132

0.97

 

R1698

782

0.54

R6844

R111057

0.1429

 

R111057

0.2333

1.00

 

N/A

-

-

R604

R13552

0.1100

 

R13552

0.1093

0.99

 

R13552

1659

0.55

R11123

R17015

0.1071

 

R17015

0.1454

1.00

 

R17015

342

1.00

R1505

R474

0.1067

 

R14797

0.2196

1.00

 

R474

366

0.56

R17044

R9470,R9417,

0.0909

 

R9470,R9417,

0.1803

0.94

 

N/A

-

-

 

R16888,R11061,

  

R16888,R11061

      
 

R111064,R14797

         

R14797

R11061

0.0700

 

R11061

0.0926

0.95

 

N/A

-

-

R13685

R14797

0.0682

 

R14797

0.0969

0.97

 

R15518

598

0.58

R15518

R474

0.0653

 

R474

0.0872

0.86

 

R13685

1067

0.57

R6900

R11061

0.0557

 

R11061

0.0805

0.98

 

R11061,R9417,

2909

0.91

        

R16888,R9470

  

R9431

R15518

0.0526

 

R13433

0.1637

0.94

 

R15518

112

1.00

R22258

R13433

0.0514

 

R13433

0.0744

1.00

 

R111083

1511

0.70

R111083

R474

0.0465

 

R13

0.2151

0.96

 

R22258

166

0.93

R13698

R15380

0.0385

 

R15380

0.3333

1.00

 

N/A

-

-

R299

R71

0.0345

 

R71

0.0345

1.00

 

N/A

-

-

R13

R474

0.0263

 

R22258

0.1303

0.97

 

R11193

688

0.79

R15380

R13698

0.0185

 

R1505

0.0260

0.98

 

N/A

-

-

  1. Validation test. The Reactome score (between 0 and 1) denotes the fraction of reactions in the query map contained in the target map (see “Validation test” Section). MIMO’s score (between 0 and 1) has been defined in Step (iv) of MIMO’s procedure. SAGA’s score (integer ≥0) denotes the level of dissimilarity between two maps: the lower the score, the higher the similarity (N/A means no hit found). The AUC values have been computed by using as gold standard the Reactome reaction overlap scores: a Reactome score greater than 0 between two maps means related and a score equal to zero not-related.