Breakpoint annotations quantify the accuracy of a smoothing model. Model agreement to annotated regions can be measured by examining the positions of predicted breakpoints (vertical black lines) observed in the smoothing model (green lines). Black circles show logratio measurements y plotted against position p for a single profile i=375. Chromosomes are shown in panels from left to right, and different values of the smoothing parameter λ in the flsa model are shown in panels from top to bottom. Models with too many breakpoints ( λ=0.5) and too few breakpoints ( λ=10) are suboptimal, so we select an intermediate model ( λ=7.5) that maximizes agreement with the annotations, thus detecting a new breakpoint on chromosome 7 which was not annotated.