Figure 2

Details of antibody sequence and structure. The IMGT® unique numbering scheme is shown in a vertical orientation. This includes the start and end points of the FR and CDR, the corresponding structures in the VH of the broadly neutralizing anti-HIV antibody 4E10, and the approximate start and end points of the V, D, and J regions. The listed starting and ending positions of the V, D, and J regions are only approximate due to the small variations in the lengths of these genes and/or owing to trimming by exonuclease. The starting and ending positions of the FR and CDR are shown with a larger font size. VL lack D genes but generally have longer V genes to compensate.