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Table 4 AA changes in the ten best predicted prototypes for the broadly-neutralizing anti-influenza antibody CH65

From: MAPs: a database of modular antibody parts for predicting tertiary structures and designing affinity matured antibodies

 

Position

Antibody

P1

P2

P3

P4

P5

P6

P7

P8

P9

P10

VH

1

E

Q

Q

Q

Q

Q

Q

Q

Q

Q

Q

36

D

G

G

G

G

G

G

G

G

G

G

38

H

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

39

I

M

M

M

M

M

M

M

M

M

M

40

N

H

H

H

H

H

H

H

H

H

H

57

H

N

N

N

N

N

N

N

N

N

N

64

D

G

G

G

G

G

G

G

G

G

G

83

A

S

S

S

S

S

S

S

S

S

S

91

V

L

L

L

L

L

L

L

L

L

L

92

N

S

S

S

S

S

S

S

S

S

S

93

G

R

R

R

R

R

R

R

R

R

R

95

K

R

R

R

R

R

R

R

R

R

R

107

G

V

G

G

G

G

G

G

G

G

G

108

G

Q

S

I

W

G

G

G

G

G

Y

109

L

L

I

V

I

I

I

I

I

I

S

110

E

E

A

G

Q

A

T

T

T

T

S

111

P

R

A

A

L

A

G

G

G

G

S

111A

R

R

R

T

W

A

T

T

T

T

W

111B

S

S

P

T

L

T

T

T

T

T

Y

111C

V

D

D

D

H

D

D

D

D

D

D

112C

D

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

V-LAMBDA

2

S

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

17

Q

Q

K

K

Q

Q

K

K

Q

K

K

27

D

N

N

N

N

N

N

N

N

N

N

36

R

S

S

S

S

S

S

S

S

S

S

42

N

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

54

V

V

I

V

V

V

I

V

V

I

V

55

C

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

56

Y

D

Y

D

D

D

Y

D

D

Y

D

116

V

V

V

V

W

A

W

W

A

A

A

117

I

V

V

V

V

V

V

V

V

V

V

123

K

K

K

K

K

Q

K

K

Q

Q

Q

126

V

V

V

V

V

V

V

V

A

V

V

  1. The AA changes of the top ten prototype (P) sequences (21 VH, 12 V-LAMBDA positions) are listed. In VH all positions outside of CDR3 have the same AA listed because the same V gene was selected. Within CDR3 different D gene selections give rise to different AA changes. In V-LAMBDA different V and J gene selections give rise to different AA changes throughout the entire domain. Sequence numbering is according to the IMGT® unique numbering [36-39].