Figure 3

Genome browser views of representative differentially bound regions. Genome browser views of two representative regions, which are found differentially bound by CBP (a) and p300 (b), using the joint modelling approach but not using the individual modelling approach. The blocks in each figure represent individual sequence reads in CBPT301 (red), CBPT302 (blue), p300T301 (black) and p300T302 (green). Additional evidence is provided from the ENCODE data on H3K4Me1 methylation marks, DNAseI hypersensitive sites and transcription factor binding, and from the Broad annotation of enhancers, promoters and actively transcribed genomic regions in GM12878, hESC and K562 cells. Region (a) is in the first intron of ARL15. We observe an overlap with CTCF binding and DNaseI hypersensitivity sites. Region (b) is 100 kb upstream of CTNNB1. It is likely functioning as a promoter or enhancer, as suggested by the annotation of histone marks provided by the ENCODE consortium and the Broad Institute.