Threshold for significance | |||||||
---|---|---|---|---|---|---|---|
P < 0.001 | P < 0.01 | P < 0.05 | |||||
Scenario* | Proportion of variants associated | RAML | SKAT-O | RAML | SKAT-O | RAML | SKAT-O |
1 | 0.05 | 78.5 | 14 | 87.5 | 22 | 96 | 42.5 |
2 | 0.05 | 69.5 | 8.5 | 84 | 18 | 93 | 36 |
3 | 0.05 | 67.5 | 9.5 | 76.5 | 21 | 85 | 38 |
4 | 0.05 | 61.5 | 6 | 72 | 18.5 | 83.5 | 32.5 |
5 | 0.05 | 68.5 | 8.5 | 78.5 | 16 | 87 | 35.5 |
6 | 0.05 | 61 | 12.5 | 75.5 | 17.5 | 82 | 30.5 |
7 | 0.05 | 65 | 9 | 79 | 21.5 | 86.5 | 37.5 |
1 | 0.10 | 75 | 14.5 | 86 | 23 | 90.5 | 40.5 |
2 | 0.10 | 61.5 | 13.5 | 81.5 | 22 | 92.5 | 39.5 |
3 | 0.10 | 59 | 9.5 | 76 | 20 | 89 | 34 |
4 | 0.10 | 58.5 | 7 | 72 | 20.5 | 84 | 41 |
5 | 0.10 | 65 | 9 | 82 | 18.5 | 89.5 | 39 |
6 | 0.10 | 61 | 9 | 79 | 15.5 | 86.5 | 31 |
7 | 0.10 | 66.5 | 5 | 83.5 | 17 | 91 | 36 |
1 | 0.20 | 83.5 | 19.5 | 95 | 41 | 99 | 63.5 |
2 | 0.20 | 63 | 9.5 | 77 | 22.5 | 93.5 | 41 |
3 | 0.20 | 66.5 | 7 | 85.5 | 22.5 | 94 | 43.5 |
4 | 0.20 | 53 | 8.5 | 72.5 | 21 | 87 | 38.5 |
5 | 0.20 | 70.5 | 10 | 86 | 25.5 | 93 | 44 |
6 | 0.20 | 59 | 11 | 79 | 20.5 | 92 | 41.5 |
7 | 0.20 | 61 | 5.5 | 79.5 | 18.5 | 89.5 | 43.5 |