Threshold for significance | |||||||
---|---|---|---|---|---|---|---|
P < 0.001 | P < 0.01 | P < 0.05 | |||||
Scenario* | Proportion of variants associated | RAML | SKAT-O | RAML | SKAT-O | RAML | SKAT-O |
1 | 0.05 | 75.5 | 53 | 87 | 66 | 90 | 80.5 |
2 | 0.05 | 72.5 | 42.5 | 85 | 66 | 90 | 78 |
3 | 0.05 | 68 | 42.5 | 79 | 57.5 | 88.5 | 73 |
4 | 0.05 | 62.5 | 35 | 76 | 50.5 | 86 | 64 |
5 | 0.05 | 57 | 36.5 | 74.5 | 50 | 84.5 | 61.5 |
6 | 0.05 | 57.5 | 35.5 | 71 | 52.5 | 84.5 | 67.5 |
7 | 0.05 | 58 | 34 | 73.5 | 48.5 | 83.5 | 64.5 |
1 | 0.10 | 84 | 62 | 90 | 79 | 93.5 | 89.5 |
2 | 0.10 | 68 | 47.5 | 80.5 | 66.5 | 87.5 | 77.5 |
3 | 0.10 | 68.5 | 50 | 81 | 65 | 89.5 | 78 |
4 | 0.10 | 56 | 37 | 70.5 | 53.5 | 80 | 68.5 |
5 | 0.10 | 66.5 | 42.5 | 80.5 | 59 | 90.5 | 78 |
6 | 0.10 | 57.5 | 38.5 | 79.5 | 53.5 | 88 | 70 |
7 | 0.10 | 63 | 41 | 83.5 | 61 | 91.5 | 73.5 |
1 | 0.20 | 90.5 | 87 | 96.5 | 96 | 99.5 | 98 |
2 | 0.20 | 70.5 | 57.5 | 84 | 75.5 | 93.5 | 85.5 |
3 | 0.20 | 74.5 | 65.5 | 89 | 79 | 96.5 | 89.5 |
4 | 0.20 | 66.5 | 54 | 80 | 72 | 92 | 84 |
5 | 0.20 | 72.5 | 58 | 86 | 72.5 | 92 | 87.5 |
6 | 0.20 | 57.5 | 41 | 76 | 61 | 90.5 | 80 |
7 | 0.20 | 60 | 41.5 | 74 | 59 | 86.5 | 76.5 |