Figure 10
From: Prediction of gene-phenotype associations in humans, mice, and plants using phenologs
Predicting mouse seizure genes from E. coli phenotypes. These mouse phenotype predictions are constructed from the k=10 nearest neighbor E. coli phenotypes, using no other species. Predicting eukaryotic phenotype-linked genes from a prokaryote is necessarily coarse-grained, due firstly to evolutionary expansions of ancestral orthologs into larger orthogroups, and secondly to the tendency for some orthologs to vanish from certain species or become unrecognizable. Nevertheless, the probability of seeing an intersection of six or more orthogroups by chance, such as that between sensitivity to tobramycin at 0.05 μg/ml and the seizure phenotype, is 1.7×10−4 (without correction for multiple testing).