Figure 8

A Venn diagram showing predictions for epilepsy based on the 40 most genetically similar phenotypes. The analysis is primarily derived from Arabidopsis, yeast, worm, and mouse, based on the Pearson sample correlation, and using cosine similarity as the weighting function. The twenty closest phenotypes are each displayed separately, and the remaining twenty are aggregated into the category “below top-20 phenotypes.” Paralogs are grouped together when they coincide at a prediction score. Genes in bold represent the orthogroups used in the search — that is, those groups of orthologous genes where one or more paralog was already associated with epilepsy in our database. Colors correspond to those in Figure 9.