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Table 2 Average computation times for obtaining normalization factors

From: TCC: an R package for comparing tag count data with robust normalization strategies

P G1

50%

70%

90%

(a) TMM

   

PDEG = 5%

0.13

0.18

0.22

PDEG = 15%

0.16

0.19

0.15

PDEG = 25%

0.17

0.14

0.15

(b) DEGES/TbT

   

PDEG = 5%

1492.92

1423.55

1573.23

PDEG = 15%

1556.93

1510.17

1408.46

PDEG = 25%

1527.08

1483.09

1543.80

(c) DEGES/edgeR

   

PDEG = 5%

3.04

3.08

3.24

PDEG = 15%

3.08

3.05

2.89

PDEG = 25%

2.99

2.92

3.05

(d) iDEGES/edgeR

   

PDEG = 5%

8.80

8.95

9.53

PDEG = 15%

8.94

8.91

8.39

PDEG = 25%

8.75

8.39

8.92

(e) iDEGES/TDT

   

PDEG = 5%

17.92

17.54

18.24

PDEG = 15%

19.85

19.45

18.74

PDEG = 25%

21.17

20.74

21.16

(f) iDEGES/DESeq

   

PDEG = 5%

17.88

17.54

18.34

PDEG = 15%

19.96

19.43

18.72

PDEG = 25%

21.17

20.75

21.27

  1. Average computation times (in seconds) of 100 trials for the six normalization methods in Table 1 are shown. The results of DEGES/TbT were obtained by using a suggested parameter setting for performing bootstrap resampling (i.e., samplesize = 10000).