Figure 4

Calibration result for a single virtual population. As described in the methods, each VPop is assessed for agreement with mean, standard deviation, and binned distribution results from clinical trial data on the basis of ACR scores. (A) The mean (dot) and standard deviation (error bar) of low-dose anti-TNF, high-dose anti-TNF therapies (infliximab, adalimumab), rituximab, and tocilizumab was calibrated to clinical trial results. (B) The ACR distribution was also calibrated to clinical trial data. The y-axis indicates the fraction in the bin. Note that every virtual population had to compare well against these criteria, with a composite goodness-of-fit p-value greater than 0.05, to be included in subsequent analyses.