Table 2 Classes for the representation of cell types and available ontologies and data sources which cover these domains

Cell types

• Names and description of cell types

• CL [10]

Cell lines

• Names and description of cell lines

• CLO [11]

• hESCReg [6]

• EFO [28]

• Characterization Tool [4]

Biological function

• Biological function

• EFO

• Molecular processs

• GO [29]

Histology

• Components and substructures

• CL

• hESCreg

• Morphology

• GO

• GO_XP_ALL [30]

• Cellular_component_xp_self [30]

• Cellular_component_xp_go [30]

• Cellular_component_xp_cell [30]

Lineage

• In vitro: origin cell

• CL

• hESCreg

• In vivo: developmental tree

• CLO

• EFO

Marker/Gene Expression

• Expressed genes

• Biological_process_xp_cell [30]

• Characterization Tool

• Biological _process_xp_uber_anatomy [30]

• hESCreg

• Biological_process_xp_multi_organism_process [30]

• Biological_process_xp_self [30]

• Biological_process_xp_cellular_component [30]

Origin

• In vivo: anatomical location in tissue/organ

• CLO

• hESCreg

• In vitro: environmental clue

• CL

• Species

• FMA [12]

• Gender

• MA [14]

• Age

• UBERON [31]

• Developmental stage

• EHDAA [13]

• uberon_anatomy_ontologies_bridge [32]