Table 1 Comparison of PKIS with kinase-specific P-site prediction tools on testing data
Kinase | PKIS | GPS2.1 | Musite | KinasePhos2.0 | PPSP | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Sn | Sp | Sn | Sp | Sn | Sp | Sn | Sp | Sn | Sp |
Erk2 (MAPK1) | 13.9% | 97.6% | 5.7% | 97.2% | 4.4% | 97.4% | 3.8% | 97.4% | 13.9% | 97.6% |
p38a (MAPK14) | 13.5% | 97.3% | 0.0% | 96.3% | 8.1% | 96.6% | 0.0% | 97.3% | 5.4% | 97.3% |
CK2alpha | 60.7% | 99.1% | 58.3% | 99.0% | 49.1% | 99.1% | 35.6% | 99.1% | 53.4% | 99.0% |
CDC2 | 37.5% | 93.3% | 12.5% | 92.0% | 0.0% | 90.3% | 0.0% | 93.2% | 12.5% | 93.2% |
PKCa | 37.3% | 99.8% | 0.0% | 99.4% | 0.0% | 99.6% | 1.7% | 99.4% | 10.2% | 99.7% |
SYK | 45.0% | 93.0% | 25.0% | 93.0% | NA | NA | 35.0% | 94.4% | 45.0% | 93.0% |
LCK | 40.0% | 97.4% | 26.7% | 92.1% | 6.7% | 93.4% | 20.0% | 96.1% | 40.0% | 97.4% |
FYN | 23.5% | 94.6% | 11.8% | 94.6% | 5.9% | 90.5% | 23.5% | 94.6% | 23.5% | 94.6% |