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Figure 4 | BMC Bioinformatics

Figure 4

From: A flexible count data model to fit the wide diversity of expression profiles arising from extensively replicated RNA-seq experiments

Figure 4

Distribution of the Poisson-Tweedie shape parameter as function of the mean expression level. Estimated Poisson-Tweedie shape parameter a as function of the mean expression level for each gene. Red dashed lines indicate the value of a corresponding to each specific distribution within the Poisson-Tweedie family, denoted by Pois (Poisson), PIG (Poisson-Inverse Gaussian), NB (negative binomial), PA (Pólya-Aeppli) and NtA (Neyman type A). The right y-axis indicates the percentage of genes around specific a values bounded by dotted grey lines. Data from Pickrell [12]et al. (2010) are shown without any normalization (a), normalized with edgeR[2](b), and normalized with cqn[4](c).

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BMC Bioinformatics

ISSN: 1471-2105

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