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Figure 5 | BMC Bioinformatics

Figure 5

From: A flexible count data model to fit the wide diversity of expression profiles arising from extensively replicated RNA-seq experiments

Figure 5

Expression dynamics of genes with different count data distributions. Empirical cumulative distributions of the breadth of expression estimated through the Barcode [18] database, for genes that do not reject the null hypothesis of a negative-binomial (NB) distribution in a test for the goodness of fit at P>0.2 (green lines), genes that do reject such a null hypothesis at P<2−16 (blue lines) and housekeeping genes retrieved from literature [19] (red lines). Data from Pickrell [12]et al. (2010) are shown without any normalization (a), normalized with edgeR[2](b) and normalized with cqn[4](c). These plots show that, independently of the normalization method, non-NB genes at such significance level of discrepancy with respect to the NB distribution approach closer the expression dynamics of housekeeping genes than genes with expression profiles following the NB distribution.

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