Figure 4
From: Differential expression analysis with global network adjustment
Histogram of p-values generated by conventional LIMMA and OSRR methods applied to the chromosomal deletion study. Note that LIMMA produces p-values that differ only slightly from a uniform distribution, but the OSRR method gives more significant p-values. The beta-uniform mixture model is shown in green and the uniform component is blue. The ratio of blue/green is the empirical Bayes probability of the false positive rate at a given p-value. This ratio approaches 0.5 for conventional analysis and it approaches 0.25 for the OSRR method.