Ontology based molecular signatures for immune cell types via gene expression analysis

BMC Bioinformatics

Table 1 Summary of GO term enrichment for all up regulated genes in particular mature B cell subtypes

B cell	Genes up regulated	Example biological process (up regulated genes)	GO ID	Genes down regulated	Example biological process (down regulated genes)	GO ID
Mature B cell	134	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	57	Antigen receptor-mediated signaling pathway	GO:0050851
B-1a B cell	91	Anatomical structure development	GO:0048856	66	Cellular chloride ion homeostasis	GO:0030644
B-1b B cell	66	Cellular chloride ion homeostasis	GO:0030644	91	Anatomical structure development	GO:0048856
Fraction F mature B cell	2	Cellular iron ion homeostasis	GO:0006879	0
Germinal center B cell	1160	Mitotic cell cycle	GO:0000278	524	Regulation of metabolic process	GO:0019222
Marginal zone B cell	99	Antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	32	Regulation of phosphate metabolic process	GO:0019220
B-1 B cell	59	Activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	GO:0007205	6	Regulation of actin polymerization or depolymerization	GO:0008064
Total	1611			776

We performed GO term enrichment for all up regulated genes in particular mature B cell subtypes. In cases where a single GO term is shown, its URI is listed.

ISSN: 1471-2105