A functional map of PDZ domain biology. An enrichment analysis of the GO biological process terms associated with the predicted gene interactors for each of the domains from structure-based and sequence-based human proteome scanning was performed. The results were visualized as a network where the nodes represent gene-sets. The colour of the node border represents the number of domains that the gene-set was seen enriched for, among the structure-based predictions. The colour of the node centre represents number of domains that the gene-set was seen enriched for, among the sequence-based predictions. Edges represent the overlap between two connected gene-sets with the thickness corresponding to the number of genes overlapping. The complete enrichment map can be downloaded for interactive viewing in Cytoscape fromhttp://www.baderlab.org/Data/StructurePDZProteomeScanning.