Schematic representation of the domain structures of NLRC5 and NLRC5-related proteins. Upper lines in grey color: Domain architecture of RI [PDB: 1Z7X]; NLRC1 [UniProtKB: Q9Y239]; NLRC2 [UniProtKB: Q9HC29]; NLRC3 [UniProtKB: Q7RTR2]; NLRC5 [UniProtKB: Q86WI3] and C2TA [UniProtKB: P33076] proteins based on data available in the PDB and the UniProtKB databases at 22th January 2013. Under lines: Domain architecture of NLRC5 and NLRC5-related proteins; the CARD and NACHT domains are indicated based on the database data and the putative LRRs are indicated based on the results of the sequence alignment and consensus sequences. uCARD domain of NLRC5 is not shown, because this domain is not indicated in the UniProt database due to its untypical nature. Domain and color legend: CARD - green, NACHT - red, LRR - magenta. Typical consensus sequences of LRRs of RI (type A and B) and NLRC5 (type 1 and 2) of NLRC5 proteins and total number of LRRs are indicated. The LRRs of NLRC5 which did not fit to the consensus pattern and length of RI-like LRR sequences are indicated with brighter magenta color.