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Table 2 Cross-validated results showing the performance of the potentials in positioning five targets with experimentally determined tilt angles

From: Membrane protein orientation and refinement using a knowledge-based statistical potential

Protein

PDB

Type

TM Subunits

MP tilt

OPM tilt

TMDET tilt

Ez-3D tilt

Hessa tilt

Experimental tilt

Lactose permease

1 pv6

Alpha

1

24.9

22.1

22.7

22.1

22.2

33 

FhuA

1qfg

Beta

1

40.0

38.8

39.2

-

-

46 

OmpA

1qjp

Beta

1

39.6

38.3

38.5

-

-

44.5 

KcsA channel

1r3j

Alpha

4

31.8

31.5

31.5

31.3

30.5

33 

Phospholamban

1zll

Alpha

5

24.9

22.5

23.8

14.0

24.4

28 ± 6 

  1. Our potential is 'MP’. Tilt angles are the average of the absolute tilt angles of all transmembrane segments, measured in degrees. Missing values indicate the method is unsuitable for beta-barrel proteins.