From: Large-scale multiple testing in genome-wide association studies via region-specific hidden Markov models
Chromosome
Region
Transition matrix
z-value distribution
(c)
(r)
(Null)
(Non-null)
1
0.98 0.02 0.03 0.97
N(0,1)
N( μ 11 ( 1 ) ,1)
2
0.98 0.02 0.03 + Ï… 1 0.97 - Ï… 1
N( μ 21 ( 1 ) = μ 11 ( 1 ) +1.5,1)
0.98 0.02 0.05 0.95
N( μ 11 ( 2 ) = μ 11 ( 1 ) +0.5,1)
0.98 0.02 0.05 + Ï… 1 0.95 - Ï… 1
N( μ 21 ( 2 ) = μ 11 ( 2 ) +2.0,1)