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Table 1 List of the genetic disorders associated to the ROCK1 target

From: Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs)

OMIM ID

Disease name

P-value

611126

Deficiency of a Acyl-coa dehydrogenase family, member 9.

1.5e-05

201450

Deficiency of acyl-coa dehydrogenase, medium-chain.

4.4e-05

201470

Deficiency of acyl-coa dehydrogenase, short-chain.

2.2e-05

201475

Deficiency of acyl-coa dehydrogenase, very long-chain.

4.2e-08

608810

Alpha-b crystallinopathy.

1.5e-05

205200

Amyotrophic lateral sclerosis, juvenile, with dementia.

5.1e-05

600996

Arrhythmogenic right ventricular dysplasia, familial, 2; arvd2.

7.9e-05

609160

Arrhythmogenic right ventricular dysplasia, familial, 7.

1.3e-05

604377

Aardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase.

4.7e-09

602067

Cardiomyopathy, dilated, 1f; cmd1f.

5.9e-05

192600

Cardiomyopathy, familial hypertrophic 1; cmh1.

7.4e-05

115210

Cardiomyopathy, familial restrictive, 1; rcm1.

7.1e-05

212350

Cataract and cardiomyopathy.

4.6e-07

601253

Caveolin 3; cav3.

7.8e-05

609060

Combined oxidative phosphorylation deficiency 1; coxpd1.

6.3e-05

610505

Combined oxidative phosphorylation deficiency 3; coxpd3.

4.4e-08

611719

Combined oxidative phosphorylation deficiency 5; coxpd5.

9.9e-07

300257

Danon disease.

6.1e-06

602668

Dystrophia myotonica 2; dm2.

3.6e-05

158900

Facioscapulohumeral muscular dystrophy 1a; fshmd1a.

2.4e-05

229300

Friedreich ataxia 1; frda.

5.5e-05

253800

Fukuyama congenital muscular dystrophy; fcmd.

8.8e-05

232300

Glycogen storage disease ii.

4.9e-06

232400

Glycogen storage disease iii.

5.3e-06

261740

Glycogen storage disease of heart, lethal congenital.

5.7e-06

261670

Glycogen storage disease x; gsd10.

4.4e-06

600737

Inclusion body myopathy 2, autosomal recessive; ibm2.

8.8e-05

167320

Inclusion body myopathy with early-onset paget disease and frontotemporal.

5.3e-05

147421

Inclusion body miositis.

2.4e-05

606183

Laryngeal abductor paralysis with cerebellar ataxia and motor neuropathy.

1.9e-05

220111

Leigh syndrome, French-Canadian type; lsfc.

7.8e-05

300322

Lesch-nyhan syndrome; lns.

8.9e-05

109150

Machado-joseph disease; mjd.

8.1e-05

248800

Marinesco-sjogren syndrome; mss.

7.9e-05

252011

Mitochondrial complex ii deficiency.

6.7e-06

609560

Mitochondrial DNA depletion syndrome, myopathic form.

3.4e-08

600462

Mitochondrial myopathy and sideroblastic anemia; mlasa.

7.2e-05

500002

Mitochondrial myopathy with diabetes.

3.1e-06

251950

Mitochondrial myopathy with lactic acidosis.

2.5e-05

610773

Mitochondrial phosphate carrier deficiency.

5.5e-08

310200

Muscular dystrophy, duchenne type; dmd.

9.5e-05

605809

Myasthenia, familial infantile, 1.

2.3e-07

610542

Myasthenia, limb-girdle, with tubular aggregates.

4.9e-06

254210

Myasthenic syndrome, congenital, associated with episodic apnea.

5.2e-07

255125

Myopathy with lactic acidosis, hereditary; hml

3.9e-07

609500

Myopathy, autophagic vacuolar, infantile-onset.

3.6e-05

609200

Myotilinopathy.

2.6e-05

258450

Progressive external ophthalmoplegia with mitochondrial dna deletions.

1.2e-05

609286

Progressive external ophthalmoplegia with mitochondrial dna deletions.

2.1e-06

212138

Solute carrier family 25 (carnitine/acylcarnitine translocase), member.

4.3e-06

103220

Solute carrier family 25 (mitochondrial carrier, adenine nucleotide.

3.9e-06

604360

Spastic paraplegia 11, autosomal recessive; spg11.

9.4e-05

610250

Spastic paraplegia 31, autosomal dominant; spg31.

8.4e-05

183020

Spinal muscular atrophy, segmental.

7.7e-05

253300

Spinal muscular atrophy, type i; sma1.

6.2e-05

609015

Trifunctional protein deficiency.

2.9e-06

222300

Wolfram syndrome 1; wfs1.

7.5e-05

  1. P-value refers to the enrichment for phenotypically correlated genes detected in the corresponding CAGC.