Gene clusters across the diffusion scales. A) The CIS genes shown in the context of the interaction network which are significant without any diffusion (β = 0). These genes represent the major sources of mutation score, and drive low scoring genes in the diffusion process. B) Overview of the identified ReMIC gene clusters at three scale levels: small-, medium- and large-scale. The color of the nodes reflects the mutation score before diffusion. Two major gene clusters, Runx- and Pik3-cluster are apparent across the scales. C) p-values of pathway enrichment analysis of three pathways in the KEGG database for two detected clusters in all diffusion scales. Both clusters are highly enriched for pathways in cancer across a range of scales. The Runx- and Pik3-cluster show strongest enrichment for the small- and large-scale, respectively. D) p-values of mutual exclusivity analysis for the two ReMIC gene clusters. Both clusters are significantly mutually exclusive across all scale levels. The minimum p-value is, however, attained for the scale at which the strongest KEGG enrichment was observed.