MFSPSSMpred: identifying short disorder-to-order binding regions in disordered proteins based on contextual local evolutionary conservation

Table 2 Performance comparisons tested on the TEST419 and TEST2012 datasets

Test dataset	predictor	ACC	TPR	FPR	AUC
TEST419	MFSPSSMPred	0.636	0.491	0.219	0.677
	MoRFpred [4]	0.603	0.254	0.049	0.673
	α-MoRF-predI [5]	0.543	0.123	0.037	NA*
	α-MoRF-predII [6]	0.580	0.258	0.098	NA*
	ANCHOR [7]	0.568	0.389	0.253	0.600
	MD [23]	0.550	0.485	0.386	0.598
TEST2012	MFSPSSMPred	0.702	0.575	0.172	0.724
	MoRFpred [4]	0.596	0.236	0.045	0.697
	MD [23]	0.589	0.613	0.436	0.679
	ANCHOR [7]	0.599	0.433	0.236	0.638
	IUPpredS [24]	0.581	0.449	0.287	0.634
	IUPpredL [24]	0.595	0.572	0.382	0.62
	MFDp [25]	0.598	0.752	0.556	0.62
	Spine-D [26]	0.599	0.72	0.522	0.605
	DISOPRED2 [27]	0.544	0.543	0.455	0.548
	DISOclust [28]	0.530	0.653	0.593	0.512

* Because the α-MoRF-predI and α-MoRF-predII generate only binary predictions, their AUC cannot be computed.

ISSN: 1471-2105