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Table 2 Gene ontology terms enriched in the 1251 siRNAs increasing mitosis duration

From: Dynamical modelling of phenotypes in a genome-wide RNAi live-cell imaging assay

 

Term

p.value

Odds.ratio

Annotated

Hit

Description

1

GO:0051437

8.7 × 10-12

7.43

70

24

Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell

      

cycle

2

GO:0032270

1.6 × 10-7

2.36

391

55

Positive regulation of cellular protein metabolic process

3

GO:0072413

2.3 × 10-7

5.60

60

17

Signal transduction involved in mitotic cell cycle checkpoint

4

GO:0000216

7.9 × 10-7

4.72

72

18

M/G1 transition of mitotic cell cycle

5

GO:0031570

9.1 × 10-7

3.59

119

24

DNA integrity checkpoint

6

GO:0008380

2.2 × 10-6

2.41

291

42

RNA splicing

7

GO:0007093

3.8 × 10-6

3.36

120

23

Mitotic cell cycle checkpoint

8

GO:0071843

1.1 × 10-5

2.59

201

31

Cellular component biogenesis at cellular level

9

GO:0000075

2.8 × 10-5

2.50

207

31

Cell cycle checkpoint

  1. Shown is a selection of GO terms that were significantly over-represented (Fisher’s exact test) with a p-value lower than 10-4. Most of the terms are related to mitosis and cell cycle regulation.