Figure 8

Time-dependent concentration of various species of the EGFR network either for the unperturbed parameter vector (solid blue lines) or for the perturbed one (dashed red lines). The 140-th most sensitive parameter (k₆₅) is ten-fold increased and the species concentrations are not affected. For the least sensitive parameters such as k₆₅, we rigorously know from the Pinsker inequality (9) that they should not alter the concentration values or any other observable even when they are heavily perturbed.